DIETARY PROPYLTHIOURACIL A N D 17fl-ESTRADIOL BENZOATE IMPLANT EFFECTS ON LIVER CARBOHYDRATE A N D LIPID METABOLISM IN CHICKS*
نویسنده
چکیده
Astrac t l . Forty-eight chicks (21 days old) were implanted (+ 50 mg 17-fl estradiol; EBI) and fed diets containing + 0.1% propylthiouracil (PTU) for 7 days to determine the role of gonadal hormones in the regulation of energy metabolism in the hypothyroid chick. 2. In vitro lipogenesis (IVL) and glucose production (NGP) were measured in liver explants. 3. Liver glycogen (GLY) metabolism was studied in particulate fractions (50,000 x g) of liver. 4. Glycogen synthetase activity (GLYSYN) was assayed in the presence of glucose-6-phosphate (G-6P; 0, 0.15 and 10 raM) to determine activation states. 5. PTU and EBI increased (P < 0.05) both GLY concentration and GLYSYN activity in chicks but, did not increase G-6P activity ratios or the in vitro activation of GLYSYN. 6. Both PTU and EBI increased (P < 0.05) IVL and NGP. 7. Estradiol magnifies the effects of PTU in chicks suggesting an interaction between thyroid status and gonadal function.
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